Allison E Ashley-Koch

Professor of Medical Genetics, Department of Medicine; Faculty Fellow of the Center for Child and Family Policy

Allison Ashley-Koch is an associate professor in the section of medical genetics, Department of Medicine at Duke University Medical Center. Her research focuses on the genetic epidemiology of Mendelian and complex genetic disorders. Another primary interest is the genetic basis of attention deficit hyperactivity disorder, particularly with respect to the influence of genetic factors which contribute to the variability in the presentation of ADHD symptoms across development. A related interest is the co-occurrence of smoking and ADHD, and the genetic liabilities which may be in common across these conditions.

Research Interests:

  • ADHD


  • Ph.D. Emory University - 1997

Recent Publications (More Publications)

  • WD Taylor, DC Steffens, A Ashley-Koch, ME Payne, JR MacFall, CF Potocky, KR Krishnan (2010) Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men. Molecular psychiatry, 15, 816-22, [doi], [abs]
  • CA Markunas, KS Quinn, AL Collins, ME Garrett, AM Lachiewicz, JL Sommer, E Morrissey-Kane, SH Kollins, AD Anastopoulos, AE Ashley-Koch (2010) Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families. Psychiatric genetics, 20, 73-81, [doi], [abs]
  • P Sebastiani, N Solovieff, SW Hartley, JN Milton, A Riva, DA Dworkis, E Melista, ES Klings, ME Garrett, MJ Telen, A Ashley-Koch, CT Baldwin, MH Steinberg (2010) Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. American journal of hematology, 85, 29-35, [doi], [abs]
  • SH Kollins, ME Garrett, FJ McClernon, AM Lachiewicz, E Morrissey-Kane, D FitzGerald, AL Collins, AD Anastopoulos, AE Ashley-Koch (2009) Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms. The Journal of nervous and mental disease, 197, 442-9, [doi], [abs]
  • S Z├╝chner, JR Wendland, AE Ashley-Koch, AL Collins, KN Tran-Viet, K Quinn, KC Timpano, ML Cuccaro, MA Pericak-Vance, DC Steffens, KR Krishnan, G Feng, DL Murphy (2009) Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Molecular psychiatry, 14, 6-9, [doi]
  • KL Deak, DG Siegel, TM George, S Gregory, A Ashley-Koch, MC Speer, NTD Collaborative Group (2008) Further evidence for a maternal genetic effect and a sex-influenced effect contributing to risk for human neural tube defects. Birth defects research. Part A, Clinical and molecular teratology, 82, 662-9, [doi], [abs]
  • AE Ashley-Koch, L Elliott, ME Kail, LM De Castro, J Jonassaint, TL Jackson, J Price, KI Ataga, MC Levesque, JB Weinberg, EP Orringer, A Collins, JM Vance, MJ Telen (2008) Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood, 111, 5721-6, [doi], [abs]
  • AE Ashley-Koch, J Jaworski, de Q Ma, H Mei, MD Ritchie, DA Skaar, G Robert Delong, G Worley, RK Abramson, HH Wright, ML Cuccaro, JR Gilbert, ER Martin, MA Pericak-Vance (2007) Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. Psychiatric genetics, 17, 221-6, [doi], [abs]
  • S Zuchner, ML Cuccaro, KN Tran-Viet, H Cope, RR Krishnan, MA Pericak-Vance, HH Wright, A Ashley-Koch (2006) SLITRK1 mutations in trichotillomania. Molecular psychiatry, 11, 887-9, [doi]
  • AE Ashley-Koch, H Mei, J Jaworski, DQ Ma, MD Ritchie, MM Menold, GR Delong, RK Abramson, HH Wright, JP Hussman, ML Cuccaro, JR Gilbert, ER Martin, MA Pericak-Vance (2006) An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder. Annals of human genetics, England, 70, 281-92, , [abs]
  • E Reid, M Kloos, A Ashley-Koch, L Hughes, S Bevan, IK Svenson, FL Graham, PC Gaskell, A Dearlove, MA Pericak-Vance, DC Rubinsztein, DA Marchuk (2002) A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). American journal of human genetics, United States, 71, 1189-94, , [abs]
  • A Ashley-Koch, ER Bonner, PC Gaskell, SG West, R Tim, CM Wolpert, R Jones, CD Farrell, M Nance, IK Svenson, DA Marchuk, RM Boustany, JM Vance, WK Scott, MA Pericak-Vance (2001) Fine mapping and genetic heterogeneity in the pure form of autosomal dominant familial spastic paraplegia. Neurogenetics, England, 3, 91-7, , [abs]
  • A Ashley-Koch, CM Wolpert, MM Menold, L Zaeem, S Basu, SL Donnelly, SA Ravan, CM Powell, MB Qumsiyeh, AS Aylsworth, JM Vance, JR Gilbert, HH Wright, RK Abramson, GR DeLong, ML Cuccaro, MA Pericak-Vance (1999) Genetic studies of autistic disorder and chromosome 7. Genomics, UNITED STATES, 61, 227-36, , [abs]
  • AE Ashley-Koch, H Robinson, AE Glicksman, SL Nolin, CE Schwartz, WT Brown, G Turner, SL Sherman (1998) Examination of factors associated with instability of the FMR1 CGG repeat. American journal of human genetics, UNITED STATES, 63, 776-85, , [abs]